People ‘know’ how to use Microsoft products. I’m a data guy and might spend less than a day a week in word, PowerPoint, excel. Most of the time I spend in them is checking other people’s work. I’m still called on to help people with such tasks as switching from footnotes to endnotes, moving files in SharePoint, fixing formatting. My general knowledge of navigating the UI and googling fixes is better than what people ‘know’.
Not nobara related but I found a Linux Mint thread about using xinput to adjust config to have left handed mode enabled for 1 mouse but not another. Maybe that will help. If they’re wireless mice with dongles, maybe they’re struggling in that one mouse is connecting to both receivers? If they offer both bt and wifi pairing you might be able to get around it by manipulating that, or if they can be plugged in that might help.
Does your monitor have speakers, or a headphone jack? Interested to see if the sound works that way. And very silly question, have you tried a different wire/device in the audio jack or only the one?
Windows 10 long term servicing channel. It’s intended for things like electronic signs but works great if you just want un bloated windows. It comes with most of the random bullshit not installed and has a longer period of security updates.